Will the Chiefs extend their winning streak?
4-0 faces off against 0-5—and the winning team also has home-field advantage. That’s the backdrop for our Chiefs vs. Chargers pick, though that doesn’t mean we’re headed for a blowout victory here. Such outcomes are extremely rare in this matchup.
In fact, the Chargers won both of their matchups against Kansas City last season, and neither roster has changed that much since then. However, the Chargers have continued to be plagued by injuries this season as well, which is why we also view them as the underdogs.
Even a surprise win against the Chiefs wouldn’t change that right now—though we don’t expect that to happen anyway. So, for Chiefs vs. Chargers, our prediction is another low-scoring matchup that will ultimately be decided by the better quarterback: Patrick Mahomes. The divisional showdown kicks off Sunday at 10:25 p.m. in Kansas City.
The bookmakers are giving the Chiefs a 7–8-point handicap here, which is, of course, due to their head-to-head records. However, this matchup has been very close every time, and there has only been one victory by a margin of more than ten points in the last ten meetings. Therefore, the odds of LA +10.5 for the Chiefs vs. Chargers are also worth considering.
Kansas City Chiefs – Los Angeles Chargers Head-to-Head Record
Surprisingly, both games last year went to the Chargers—though by margins of just three and six points, respectively. In fact, nine of the last ten matchups were one-score games that were practically decided on the final possession.
Despite the Chiefs having had a much better season so far, this is still the NFL, where anyone can beat anyone (even the Titans). So, for Chiefs vs. Chargers, the betting odds on Kansas City with this high spread should be taken with a grain of salt. That said, it’s still very possible they’ll come out on top in the end. For those looking to bet on the Chiefs, we recommend combination bets on Kansas City + the under. The 40-point total has been exceeded only once in their last five games.
Kansas City Chiefs – Los Angeles Chargers Pick
How well will the Chiefs come out of their bye week? For teams that were on a roll beforehand, a bye week can sometimes have a cooling effect. That said, we don’t expect that to be the case for Kansas City here, even if they might need a little time to get back into gear.
We don’t expect a high-scoring affair, especially in the first half, which should also affect the total points—as is often the case in this matchup. Therefore, for Chiefs vs. Chargers, our betting recommendation is to go with Under 42.5 total points.
For our player bet, we’ve settled on the Chiefs’ big man: Travis Kelce. Mahomes relies heavily on his tight end, especially in home games, and threw him the ball 11 times in their last home game (9 catches + 1 touchdown). A touchdown bet on Kelce at very strong odds is therefore also a good option.

