Will the Eagles defense dismantle the 49ers too?

Eagles vs. 49ers, and no, we’re not even close to Super Bowl 2026, but only in the first playoff round. However, the matchup is extremely high-class, as evidenced by the two records (11-6 and 12-5), which makes our Eagles vs. 49ers tip a real treat.

The Niners even have the slightly better regular season record. Nevertheless, neither the bookmakers nor we consider them the favorites. Why? They have a very weak defense, and this becomes increasingly important in the playoffs.

The Eagles allow an average of 19.1 points, although this figure is also due to their weaker start to the season. Over their last four games, they have conceded only 13.5 points on average, which shows the direction we are heading in here.

So, for Eagles vs. 49ers, our prediction is a dominant defensive performance from Philly, which will leave San Francisco with little chance.

The Eagles are the favorites, but not so much that betting on them is no longer worthwhile, as our top tips show. We also take into account that Philly always starts games very strongly and has won the first quarter in three of their last four games.

Philadelphia Eagles – San Francisco 49ers Head-to-head comparison / H2H record

Eagles fans have fond memories of the last game in Philadelphia, which ended in a clear 42-19 victory for San Francisco. However, that was back in 2023, when the 49ers still had a much more stable defense.

In addition, the Niners are currently plagued by injuries, with four starters definitely out and others (Winter, Gifford) questionable. Offensive tackle Trent Williams and wide receiver Ricky Pearsall are also more than just questionable. If these two key players are out, we see the 49ers’ chances as close to zero.

So, in Eagles vs. 49ers, the odds on Philly are much more playable – both as a combination bet and with a handicap of up to -5.5 points. We can also clearly recommend betting on Philly to win the first quarter. What’s more, this bet is currently even enhanced with the odds boost at Interwetten.

Philadelphia Eagles – San Francisco 49ers Tip

Fred Warner, Brandon Ayiuk, Nick Bosa, Mykel Williams, Patrick Taylor, Tatum Bethune – these are just a few of the top players on the 49ers who will definitely be out on Sunday. The Eagles, on the other hand, are relatively complete and could even get Phillips and Johnson back.

Another point that clearly speaks in Philly’s favor in our eyes, making a bet on Philadelphia definitely playable for Eagles vs. Niners. Our favorite: a bet on the Eagles in the 1st quarter, as they have already won it eight times this season.

For an alternative player bet, we are also sticking with Philly with a bet on a touchdown by Dallas Goedert. He has been in really good form recently and has found the end zone four times in his last three games.